Human Growth Hormone Peptides
Commonly referred to as growth hormone secretagogues, meaning they induce secretion, there are two primary categories or classifications of human Growth Hormone (hGH) peptides- Growth Hormone Releasing Hormones (GHRH’s) and Growth Hormone Releasing Peptides (GHRP’s). The basis of function for both is to physiologically elevate Growth Hormone (GH) and IGF-1 levels. Growth hormone has roles in stimulating growth, cell reproduction and cell regeneration; in children promoting growth and in adults helping to maintain normal body structure and metabolism. Insulin-like Growth Factor, or IGF-1, is stimulated by growth hormone and has an anabolic effect in adults.
Growth hormone is released in pulses throughout the day, with the highest release typically being in Stage IV sleep, which also happens to coincide with repair of the body. These pulses stimulate growth hormone release into the blood stream from the anterior pituitary. It is a complex and delicate balance between the body and the brain that maintains growth hormone at appropriate levels. The release of growth hormone is controlled by growth hormone releasing hormone, or GHRH, from the hypothalamus. This release stimulates the anterior pituitary to release growth hormone, while somatostatin inhibits the release of growth hormone. There are also external factors influencing production such as sleep, stress, exercise and low blood glucose as well as puberty, that can stimulate GH release; while increased growth hormone or IGF levels in the blood and pregnancy can decrease release.
Why is all this important? Well, as we age, one of the first things we lose is Stage IV sleep; therefore, not only the highest pulse of growth hormone but the repair processes and functions within the body become diminished. It has also been been theorized that aging results in increased somatostatin inhibition which further potentiates decreased growth hormone production. While growth hormone may not provide the complete answer to aging, it is apparent that decreasing levels of growth hormone and IGF-1 play a crucial role in the aging process and how depleted levels can impact and accelerate aging.
Processes occurring with Aging
- Decrease in IGF-1, GH
- Increase in cellular cortisol levels
- Muscle loss or wasting
- Decreased insulin sensitivity
- Decreased cognition and memory
- Increased reactive oxygen species
- Decreased steroidal production
Benefits of Growth Hormone Peptide Therapy
- Improved immunity/immune function
- Decreased inflammation systemically
- Cardiac protection and vessel vasodilation leading to improved blood pressure
- GI protection and repair
- In the brain, clearance of beta-amyloid which is found in Alzheimer’s Disease
- Anti-depressant and anti-anxiety effects
- Stress protection
- Improved renal/kidney function and integrity
- Improved pain
- Reduced recovery from injury
- Improved arthritis
- Muscular growth and development
Current Research Areas
- Cachexia or wasting
- Cardiovascular Disease
- Chronic Renal Failure
- Chronic Respiratory Disease
- Cancer treatment
*Every study has shown a positive effect or improvement with use
Ipamorelin is considered a Growth Hormone Releasing Peptide or GHRP. It is comprised of 5 amino acids. Ipamorelin is Ghrelin like in nature and functions to stimulate the release of growth hormone from the anterior pituitary. It significantly increases plasma growth hormone levels, safely and without side effects. Ipamorelin helps your body decrease fat, increase lean muscle mass, increase collagen production, achieve better, more restorative sleep, increase bone mineral content, increase cellular repair and regeneration, amongst many other benefits.
CJC 1295 is a modified form of growth hormone releasing hormone (GHRH) that results in increased production of growth hormone. It is comprised of 30 amino acids containing the first 29 amino acids of GHRH, similar to Sermorelin, but has an additional amino acid. What this modification allows for is an increased half life, from approximately 10 minutes with Sermorelin to 30 minutes with CJC-1295. Ultimately, this leads to the requirement of a lesser dose for the same results in comparison with Sermorelin. The benefits of CJC-1295 include increase in growth hormone release resulting in increased muscle growth, increase in bone density, increased concentration and memory, increase in fat loss and weight reduction, increase in collagen, and increase in cellular repair.
Sermorelin is a growth hormone secretagogue comprised of 29 amino acids. It functions similar to Growth Hormone Releasing Hormone (GHRH) produced by the hypothalamus. Sermorelin increases synthesis and release of growth hormone from the pituitary gland to increase serum levels of growth hormone and IGF-1. Sermorelin supports natural human Growth Hormone, hGH, production which is crucial for cell regeneration and reproduction. Ultimately, leading to improved energy and vitality, enhanced cognitive function, decreased body fat through increased lean muscle mass, better sleep and overall anti-aging benefits.
Macimorelin is a synthetic growth hormone secretagogue that is FDA approved for the diagnosis of adult growth hormone deficiency. Macimorelin mimics ghrelin, a peptide hormone known to cause a release of growth hormone. It functions by binding to the receptor that activates growth hormone in the hypothalamus and pituitary gland to stimulate the release of growth hormone into the circulatory system. Macimorelin is currently undergoing numerous clinical studies for proper dosing and degree of positive outcomes, one of which Re-new Institute is a participant. Macimorelin is not well known to most practitioners and with its oral administration and safety profile, widely underutilized.