Sermorelin is an FDA approved therapy that is a safe and generally well-tolerated way to increase one’s natural production of human Growth Hormone (hGH).  Also known as GRF 1-29, it is comprised of 29 amino acids and is the shortest known fully functional fragment of growth hormone releasing hormone (GHRH).  It is the most widely used Growth Hormone therapy worldwide.  Sermorelin acts on the GHRH receptor in the pituitary gland to regulate cellular activities.  It is this receptor that regulates growth hormone release both directly and indirectly through a feedback mechanism with somatostatin.  The result is increased synthesis and release of growth hormone from the pituitary gland, leading to elevated serum growth hormone and IGF-1.  Sermorelin through its actions is able to increase both the amplitude and frequency of growth hormone pulses.


Benefits of Sermorelin

  • Increase in lean body mass
  • Decreased body fat %
  • Increased metabolism
  • Increased energy
  • Increased slow wave sleep
  • Accelerated wound healing and recovery
  • Increased strength and endurance
  • Improved immune function
  • Enhanced cardiovascular function
  • Increased bone mineral density
  • Increased collagen production
  • Improved skin and hair quality

When Can I Expect To Experience Improvements?

While some patients will begin to experience improvements within the first several weeks of starting therapy, many of the full benefits are not experienced until months 4-6. It is for this reason that treatment with Sermorelin, or any human Growth Hormone peptide regimen, is recommended as a 6 month treatment cycle.

Month 1

  • Increased energy
  • Improved stamina
  • Deeper, more restful sleep

Month 2

  • Improved skin, reduced wrinkles
  • Stronger nails and hair
  • Increased metabolism

Month 3

  • Enhanced sex drive and performance
  • Improved mental focus
  • Improved joint health

Month 4

  • Continued weight reduction
  • Improved skin elasticity
  • Increased lean muscle mass

Month 5

  • Noticeably fuller and healthier hair
  • Reduced appearance of wrinkles, better skin tone
  • Continued reduction in belly fat

Month 6

  • 5-10% reduction in body fat (without exercise/diet)
  • 10% increase in lean muscle mass
  • Improved vitality due to organ regrowth

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What is Sermorelin?

Sermorelin is the shortest, fully functional fragment of growth hormone releasing hormone.  It is comprised of 29 amino acids.  It acts to increase growth hormone production from the pituitary gland.

How does Sermorelin work?

Sermorelin is the first 29 amino acids of Growth Hormone Releasing Hormone (GHRH) produced in the hypothalamus.  GHRH acts on the GHRH receptor in the pituitary gland which regulates the release of growth hormone.  Sermorelin increases growth hormone release directly from the pituitary gland and increases IGF-1 production in the liver and peripheral tissues.

What are the side effects of Sermorelin?

Sermorelin is generally well-tolerated and safe.  Sermorelin due to its action on the pituitary gland has been shown to increase cortisol and prolactin levels.  It also can activate Ghrelin which leads to an increase in hunger.  If administered subcutaneously, local injection site reactions such as redness, irritation, soreness and bruising, while typically short-lived, can occur.  Other extremely rare side effects of Sermorelin include dizziness, headache, flushing, fatigue and restlessness.  It is critical to consult a medical profession prior to use and if any side effects should develop with use of Sermorelin.

How is Sermorelin administered?

Sermorelin is commonly administered in a subcutaneous injection.  However, at Re-new Institute it is also available in convenient sublingual troches and rapid dissolve tablets, giving patients who are hesitant to administer injections or want the ease of an oral option.  In some instances, Sermorelin can also be available in a sublingual dropper.

How long should I take Sermorelin?

Sermorelin is best taken consistently and consecutively for 6 months, for maximum benefit.  It is safe to stay on long term. However, one of the potential side effects is antibody formation to Sermorelin with chronic subcutaneous administration at high doses. The long term detriment to such antibody formation is unknown, however would suggest decreased efficacy to Sermorelin.  For this reason, the use of Sermorelin should only be prescribed by a medical professional trained in peptide therapy and understands the complexities of growth hormone therapy.

How is Sermorelin dosed?

Dosing of Sermorelin is contingent on each individual patient and the goals they are looking to accomplish.  Sermorelin has a relatively short half-life between 9-11 minutes, often meaning that more is required for the same effect when compared to other growth hormone peptides.  However, due to the risk of antibody formation, it is important to determine the accurate dose for each patient and remember that higher dosing is not always ideal.  At Re-new Institute, our peptide trained physicians will help you safely find the dose for you to accomplish your goals.

When is the best time to take Sermorelin?

Timing of Sermorelin is dependent on goals each individual is wanting to accomplish, and therapy is specifically designed to those desires.  There are better times of the day to take Sermorelin based on desired outcomes.  Effectiveness of Sermorelin can be directly influenced by dietary factors.

Is Sermorelin a steroid?

No, Sermorelin is not a steroid.  It is a peptide that acts on the pituitary gland to increase growth hormone production.

Can Sermorelin be combined with other therapies?

The easy answer is yes!  Sermorelin is often is prescribed in combination with other peptide therapies, including other human Growth Hormone peptides such as Ipamorelin for enhanced results.  Sermorelin has been newly compounded with Glycine for enhanced and synergistic results.  Glycine is an amino acid that has a role in control of hypothalamic and pituitary functions.  It induces the pituitary to secrete hGH.  In an ideal combination with Sermorelin, the two provide amplified weight loss, fat burn and increased lean muscle mass.  It is important to discuss your goals with the physicians at Re-new Institute, so that we can determine the best regimen or combination for you.

Am I a candidate for Sermorelin?

Generally speaking, Sermorelin is safe for both men and women over the age of 25.  There are no limitations on age beyond 25 years old.  Due to its growth properties, Sermorelin is generally avoided in anyone with active cancer or intracranial lesions.  It is important to notify a Re-new provider if you are on medication to treat thyroid disease or take corticosteroids.  On occasion, a less than desired response can be seen in those with a history of obesity, elevated blood glucose levels or hyperlipidemia.  A complete history and physical interview with a Re-new provider as well as some basic blood work, will help determine if you are a candidate for Sermorelin peptide therapy.  Contact our peptide trained physicians at Re-new Institute today to schedule your consultation.

What are the benefits of Sermorelin?

Growth Hormone plays many roles in human body spanning from stimulating growth, cell reproduction and cell regeneration, to maintaining normal body structure and metabolism.  Sermorelin is an analog of Growth Hormone Releasing Hormone, acting on the pituitary to increase the production of growth hormone and IGF-1 with benefits including enhanced weight loss, increased fat burn, increased lean muscle mass, improved sleep, increased energy and less fatigue, enhanced mental cognition and memory, improved skin elasticity, tone and texture as well as other anti-aging benefits, and many more.  For a more detailed list, see above or contact Re-new Institute to learn more.

Which is better-Sermorelin or Ipamorelin?

Ideally, it is about determining your goals, in conjunction with past medical history and current medications, to develop an individualized plan to meet your needs.  Sermorelin and Ipamorelin will both increase growth hormone production but in different ways and with different potential side effects.  They are safe in combination with each other to increase effectiveness.  Contact Re-new, to obtain your personalized health and wellness plan.

Does Sermorelin cause weight gain?

Typically, no, Sermorelin will not cause weight gain.  With appropriate use, it should increase weight loss as well as fat reduction.  It is important to optimize exercise and a well-balanced diet for ideal weight loss, in addition to Sermorelin.

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