Macimorelin is a synthetic growth hormone secretagogue that is FDA approved for the diagnosis of adult growth hormone deficiency.  Macimorelin mimics ghrelin, a peptide hormone known to cause a release of growth hormone.  It functions by binding to the receptor that activates growth hormone in the hypothalamus and pituitary gland to stimulate the release of growth hormone into the circulatory system.  Macimorelin is currently undergoing numerous clinical studies for dosing and degree of efficacy or desired outcomes, one of which Re-new Institute is a participant.  Macimorelin is not well known to most practitioners and with its oral administration and safety profile, widely underutilized.


Benefits of Macimorelin

  • Increase in lean body mass
  • Decreased body fat %
  • Increased metabolism
  • Increased energy
  • Increased slow wave sleep
  • Accelerated wound healing and recovery
  • Increased strength and endurance
  • Improved immune function
  • Enhanced cardiovascular function
  • Increased bone mineral density
  • Increased collagen production
  • Improved skin and hair quality

When Can I Expect To Experience Improvements?

While some patients will begin to experience improvements within the first several weeks of starting therapy, many of the full benefits are not experienced until months 4-6.  It is for this reason that treatment with Macimorelin, or any human Growth Hormone (hGH) peptide regimen, is recommended as a 6 month treatment cycle. 

Month 1

  • Increased energy
  • Improved stamina
  • Deeper, more restful sleep

Month 2

  • Improved skin, reduced wrinkles
  • Stronger nails and hair
  • Increased metabolism

Month 3

  • Enhanced sex drive and performance
  • Improved mental focus
  • Improved joint health

Month 4

  • Continued weight reduction
  • Improved skin elasticity
  • Increased lean muscle mass

Month 5

  • Noticeably fuller and healthier hair
  • Reduced appearance of wrinkles, better skin tone
  • Continued reduction in belly fat

Month 6

  • 5-10% reduction in body fat (without exercise/diet)
  • 10% increase in lean muscle mass
  • Improved vitality due to organ regrowth

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What is Macimorelin?

Macimorelin is growth hormone secretagogue that mimics ghrelin leading to increased growth hormone release from the pituitary.

What are the side effects of Macimorelin?

Side effects of Macimorelin include dizziness, headache, fatigue, nausea, increased hunger, flushing and diarrhea.  However, at appropriate dosing, experience of side effects has been demonstrated to be extremely rare. 

How is Macimorelin administered?

Macimorelin is available in oral form, making it ideal for those who wish to avoid subcutaneous injections.

Is Macimorelin safe?

Yes, Macimorelin is considered safe at appropriate dosing with a low side effect profile.

How long should I take Macimorelin?

Ideal results from Macimorelin are achieved when taken consistently and consecutively for 6 months.  It is safe to stay on long term. However, because of it’s relative newness to the market, the use of Macimorelin should only be prescribed by a medical professional trained in peptide therapy with knowledge of Macimorelin.

Am I candidate for Macimorelin?

Macimorelin is safe for both men and women over the age of 25, with no cap on age, although the health and wellness of individual patients will play a factor.  Macimorelin should be avoided in patients with a history of traumatic brain injury or pituitary adenoma.  Anyone with unexplained weight changes, struggles with obesity or has uncontrolled cardiovascular or metabolic disease, should consult with a medical provider prior to starting therapy with Macimorelin.   A complete history and physical with a Re-new physician, as well as some basic blood work, will help determine if you are a candidate for treatment with Macimorelin.  Contact Re-new Institute today to schedule your consultation.

Can Macimorelin be combined with other therapies?

While significant benefits can be obtained with Macimorelin treatment only, it is safe in combination with GHRP’s such as Ipamorelin for maximum results.

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