Thymosin Beta-4

Thymosin Beta-4, also known as TB-4, is naturally occurring, ubiquitous peptide with a sequence of 43 amino acids.  It is isolated from the thymus glad and occurs in nearly every cell.  Thymosin Beta 4 is water soluble, meaning that it won’t get stored in the body if in excess.  It works by upregulating ACTIN, a multi-functional protein that is essential for cellular functions such as the mobility and contraction of cells during cell division, as well as a role in cell signaling. 

Thymosin Beta 4 has shown roles in blood vessel formation, cellular migration and stem cell maturation, leading to a long list of potential uses from cardiac to neurological to anti-inflammatory.  TB-4 has been used in clinical trials to promote healing in injuries to the heart, skin and cornea, to name a few.  It has been shown to aide in the formation of new heart muscle cells after the heart has sustained damage from a cardiovascular event such as a heart attack or MI.  Thymosin Beta-4 is essential for the recovery in both the peripheral and central nervous systems by helping support neurovascular remodeling, which may prove a promising treatment for brain injury and neurodegenerative diseases.  It also exerts significant anti-inflammatory properties, all while suppressing pro-inflammatory markers.  TB-4 assists in the distribution of bacterial fighting agents following bacterial infections. 


Potential Benefits

  • Supports immunity
  • Antimicrobial
  • Soft tissue repair
  • Reduced joint inflammation
  • Enhanced tissue repair and muscle development
  • Accelerated healing and reduced recovery times
  • Decreased scar tissue formation
  • Increased collagen deposition
  • Neuroprotection
  • Cytoprotection
  • Promotes angiogenesis, new blood vessel formation
  • Improved cardiac wound repair

Disease States or Conditions That May Benefit from Thymosin Beta 4

  • Those looking to optimize the healing process following ortho-related or other soft tissue injuries
  • Pressure or venous stasis ulcers
  • Neurodegenerative conditions such as stroke, Multiple Sclerosis (MS), Traumatic Brain Injury (TBI) or concussion
  • Ischemic stroke
  • Spinal cord injuries
  • Autoimmune conditions or those requiring immune response modulation
  • Inflammatory conditions such as some forms of arthritis
  • Lyme’s Disease
  • Corneal injury
  • Dry eye disorders
  • Lung inflammation and fibrosis
  • Cardiac related injuries such as ischemic or hypoxia injuries, including MI or infarct
  • Non alcoholic fatty liver disease
  • Hair restoration
  • Sepsis

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Who is a candidate for Thymosin Beta 4?

Anyone who is looking for accelerated healing or wishing to better manage symptoms associated with a chronic condition.  Those who have experienced any of the symptoms or conditions listed above may be ideal patients for treatment with TB-4.

Can Thymosin Beta-4 be used in combination with any other medications?

Yes, as far as additional peptide therapies, Thymosin Beta 4 works great in combination with Thymosin Alpha 1.  It can also be used in conjunction with BPC 157.  In relation to traditional medications you may be prescribed, it is critical to inform our physicians what medications you are taking so that we can determine the best and safest treatment regiment for you.  With that being said, Thymosin Beta-4 is generally safe with most medications.

What is Thymosin Beta 4 used to treat?

Thymosin Beta-4 is used to treat a multitude of possible conditions and disease states from wound repair and healing to pulmonary/lung or cardiac/heart conditions to brain/spinal cord injuries and neurodegenerative conditions.  For a more comprehensive list, see above or contact Re-new Institute today to discuss your personal medical history and determine if you are a candidate for Thymosin Beta 4.

What is Thymosin Beta-4 made of?

Thymosin Beta 4 is a regenerative peptide comprised of 43 amino acids.  It is isolated from the thymus glad and is water soluble, meaning that is can maneuver quickly and easily around the body without the worry of accumulation of excess

What are the side effects of Thymosin Beta 4?

The side effects of TB-4 are typically very minimal and transient, or short lived.  One of the most common side effects is redness, itching or discomfort at injection site.  This will usually resolve within 10 minutes to several hours following injection.  Some others may experience increased fatigue or headache with injection, neither should last more than 24 hours.  It is important to discuss any reaction or side effects you experience with your physician at Re-new Institute.

How is Thymosin Beta-4 administered?

The most common form of Thymosin Beta 4 is administered in a subcutaneous injection.  It is also recommended that it be dosed in a cyclical fashion.

How long should I take Thymosin Beta 4?

It is generally recommended that Thymosin Beta-4 be dosed or given in a cyclical manner due to its high affinity for growth and proliferation.  Your physician at Re-new Institute will discuss your condition as well as obtain a comprehensive past medical history from you to determine appropriate dosing and treatment regimen.  Common use of TB-4 is a 3 month continuous cycle, then breaking from therapy.

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