Thymosin Alpha 1

Thymosin Alpha 1, also known as TA 1, is a naturally occurring peptide comprised of 28 amino acids and is isolated from the thymus.  One of it’s key roles is to modulate innate immunity through T cell differentiation and maturation, and decreasing T cell apoptosis or death.  A T cell is a type of lymphocyte derived from the thymus gland that plays an important role in controlling and shaping the immune response.  One of the integral roles of TA-1 is balancing Th1 with Th2.  While, Thymosin Alpha-1 has many uses, it gained FDA approval for malignant melanoma. 

Why is Th1 and Th2 balance important?

An imbalance between the two leads to immune dysfunction, which many do not realize can be associated with numerous symptoms and conditions including:

  • Chronic Stress
  • Depression
  • Metabolic Syndrome
  • Weight Management issues
  • Insulin Resistance and Type 2 Diabetes
  • Increased aging effects due to increased oxidative stress
  • Chronic Fatigue Syndrome
  • Fibromyalgia
  • Autoimmune conditions
  • Cancer
  • Chronic illness
  • Chronic infections such as Lyme’s disease, viral, Candida, parasitic
  • Environmental toxins
  • Food sensitivities/allergies
  • Zinc and selenium deficiencies
  • To name a few…

While that list is long and overwhelming, the take away is that immune function is crucial and an imbalance can lead to virtually any condition or disease state.

Potential Benefits

  • Increased innate and adaptive immunity
  • T cell differentiation and maturation
  • Decreased T cell death
  • Improved Th1 response
  • Balanced Th1 with Th2
  • Enhanced dendritic cells, which act as messengers between the innate and adaptive immune systems
  • Enhanced antibody response
  • Blocks steroid induced apoptosis or death of thymocytes
  • Anti-tumor effects
  • Protection against oxidative damage

Disease States or Conditions that may Benefit from Thymosin Alpha 1

  • Any condition requiring immune modulation or support
  • Hepatitis B and C
  • Treatment of HIV/AIDS
  • Cancer
  • Chronic Fatigue
  • Fibromyalgia
  • DiGeorge’s Syndrome
  • Decreased response to vaccinations
  • Lyme’s Disease
  • Chronic inflammatory conditions
  • Sepsis
  • Adjunct to metastatic breast cancer therapies
  • Malignant Melanoma
  • Used to reduce hematologic (blood) toxicity of cytotoxic drug therapies
  • And MANY others…

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Who is a candidate for Thymosin Alpha 1 therapy?

Anyone needing or wanting to increase immunity or who has an autoimmune condition would be an ideal patient for Thymosin Alpha-1.  For a more complete list of conditions that may benefit from TA-1, please see above or contact Re-new Institute today.

What is Thymosin Alpha-1 used to treat?

Thymosin Alpha 1 can be used to treat a wide variety of conditions and diseases ranging from chronic fatigue and metabolic syndrome to fibromyalgia and Lyme’s disease.  It has been shown to also provide benefit for some allergies, autoimmune conditions and cancer.  Thymosin Alpha-1 is undergoing clinical trials for use in the treatment of COVID-19, specifically in the elderly population.  For a more comprehensive list, refer to above or contact Re-new today to discuss with our physicians.

Is Thymosin Alpha 1 FDA approved?

Yes, Thymosin Alpha-1 has FDA approval for the treatment of malignant melanoma, as a drug also known as Zadaxin.

Can Thymosin Alpha-1 be used with other treatments or therapies?

Yes, as far as additional peptide therapies, Thymosin Alpha 1 works great in combination with Thymosin Beta 4.  It can also be used in conjunction with BPC 157.  In relation to traditional medications you may be prescribed, it is critical to inform our physicians what medications you are taking so that we can determine the best and safest treatment regiment for you.  With that being said, Thymosin Alpha-1 is generally safe with most medications.

What is Thymosin Alpha 1 made of?

Thymosin Alpha-1 is a naturally occurring peptide comprised of 28 amino acids and is produced from the thymus gland.

How long is treatment course with Thymosin Alpha 1?

Typical treatment with Thymosin Alpha-1 can range anywhere from 2 weeks to 3 or more months.  Although it is generally not administered daily, there is some data supporting daily use.

What are the common side effects from Thymosin Alpha-1?

As common with any injection, particularly subcutaneous injections, there may be some redness, itching or soreness at injection site.  It is typically not bothersome and is short-lived.  On rare instances, some patients will experience increased fatigue and joint pain, similar to flu-like symptoms with Thymosin Alpha 1.  It is crucial to consult with your physician at Re-new Institute should you develop any side effects from the use of Thymosin Alpha-1.

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